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KMID : 0376419880120030241
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Chonbuk University Medical Journal
1988 Volume.12 No. 3 p.241 ~ p.255
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Regeneration of hepatic Tissue following Partial Hepatectomy of the Liver With CCl-induced Hepatic Injury
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Choi Sam-Im
Kang Myoung-Jae
Song Hee-Jong
Lee Sang-Hyun
Lee Hye-Soo
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Abstract
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To investigate the origin of macrophages in the nontraumatic infarcted site of brain, time sequential (one, 2, 3, and 4 weeks) routine histologic and histochemical examinations and GFA(glial fibrillary acidic protein) detections with PAP(peroxidase-antiperoxidase) technique were performed after brain infarction was induced by injection of autologous blood clot, and following results were obtained.
1 . Grossly, brain infarcts were observed mostly in the right parietal and temporal lobe and ischemic. Infarcted areas of one week old appeared edematous and of two week old were necrotic and clearly demarcated with surrounding brain tissue. In the three week old infarcts, a line of demarcation between the lesion and surrounding brain tissue were more distinct and slightly contracted. And four week old infarcts were more contracted,
2 . In Iiistologic and histochemical changes, one week old infarcts were characterized by generalized edema, parenchymal degeneration and necrosis, and acute inflammatory changes with infiltration of gitter cells. Two week old infarcts showed pseudocystic changes with chronic inflammatory cell infiltrations, proliferation of pericystic cells and capillaries, and evidence of phagocy Losis and mitosis in infiltrating cells. In three week old group, size of cysts were smaller, and pericystic cell number and capillary proliferations were slightly decreased, but phagocytosis and mitotic figures were persistent. In four week old group, number and size of pseudocysts were decreased and contracted, and cells of the surrounding the lesions were decreased and gliosis were noticed.
3. Although cellular composition in the infarcts were variable according to the experimental group, in all experimental group, GFA positive astrocytes and GFA negative cells were observed, and some of these cells showed mitotic figure. It is thought the GFA nega
tive cells consists of many microglia according to their morphological features.
According to these results, it is considered that macrophages in the brain infarcts originated from multiple sources, both blood monocytes and microglial cells according to the causes of infarcts and time after lesion.
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KEYWORD
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Partial hepatectomy, CCL₄, Regeneration, Hepatic tissue
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